The Quebrada de Humahuaca is a narrow mountain valley in the province of Jujuy, northwest Argentina, about 1,649 kilometers (1,025 miles) north of Buenos Aires. It is approximately 155 kilometers (96 miles) long, stretching from north to south. The valley is bordered by the Altiplano to the west and north, by the Sub-Andean hills to the east, and by the warm valleys (Valles Templados) to the south.

The word "quebrada" means "broken" and refers to a deep valley or ravine. The name comes from Humahuaca, a small city with about 11,000 people. The Grande River (Río Grande) flows through the Quebrada during the summer but is dry in the winter.

This region has been an important place for trade, social interactions, and cultural exchanges for thousands of years. People have lived here for at least 10,000 years, as shown by many old remains from long ago. The area includes many stone-walled agricultural terraces, which were built more than 1,500 years ago and are still used today. These terraces connect a series of strongly built towns called pucaras. Later, the valley was used as a caravan road by the Inca Empire in the 1400s. It also became an important link between the Viceroyalty of the Río de la Plata and the Viceroyalty of Peru. The valley was also a location for many battles during the Spanish War of Independence.

The Quebrada de Humahuaca was declared a protected landscape in 2000. It was added to the UNESCO World Heritage Site list on July 2, 2003.